Protein Expression Market Size, Share, By Product (Kits and Reagents, Vectors, Competent Cells, and Instruments), Expression System (Mammalian and Non-Mammalian), Application (Therapeutic, Industrial, and Research), End-User (Pharmaceutical and Biotechnology Companies, Academic Research, Contract Research Organizations, and Others), and Region - Trends, Analysis, and Forecast till 2035

• By 2035, the market is expected to be USD 7.9 Billion.
• Protein expression market size was valued at USD 4.0 Billion within 2024.
• Target market is developing at a CAGR of 7.2%.

The process of turning DNA into proteins is known as protein expression. Translation and transcription are involved in this basic biological activity. The protein expression market is the industry that develops and employs technology to manufacture, alter, and control proteins. It is expanding as a result of the need for more effective manufacturing techniques and the demand for protein therapies.

The increased demand for biopharmaceuticals, rising government funding, advancements in biotechnology and artificial intelligence, increasing outsourcing of clinical activities, and the growing shift toward personalized medicine is contributing in driving protein expression market growth. Moreover, protein expression aids in rapid production, is cost-effective, and has the ability to express a wide range of proteins, thus further boosting the market growth.

AI Impact on the Market:

Protein expression market is being profoundly impacted by artificial intelligence (AI), which makes it possible to predict protein structures and functions with high accuracy, optimize protein design, analyze complex proteomics data, and create new proteins with better properties. By enabling targeted manipulation of protein expression levels, AI ultimately speeds up drug discovery and other biotechnological applications.

Key Drivers of Target Market:

Rising Demand of Protein Expression in Biopharmaceutical Industries is Skyrocketing the Market Growth

The process of producing a particular protein within a cell is known as protein expression. In the context of biopharmaceuticals, it refers to the large-scale production of therapeutic proteins used in medications such as vaccines and antibodies, which is motivated by a rising demand in the biopharmaceutical industry for highly targeted and efficient protein-based treatments; in other words, as the demand for biopharmaceuticals rises, so does the requirement for reliable protein expression techniques to produce these drugs effectively.

• For Instance, June 2023, KBI Biopharma, Inc. (KBI), a JSR Life Sciences company, announced the launch of KBI PUREplatform, a premium microbial cell line development (CLD) platform that features unmatched efficiencies in a microbe’s protein expression system for biopharmaceutical production. KBI's therapeutic protein platform addresses industry challenges such as low titers, poor product quality, and capacity constraints, empowering customers to improve processes and bring products to market cheaper and easier.

Restraints:

Slow Production Time of Protein Expression is limiting the Market Expansion

A slow production time for protein expression can be caused by a number of factors, such as the time-consuming multi-step transcription, translation, folding, and possible post-translational modifications processes, potential host cell metabolic limitations, problems with protein stability, and the necessity of optimizing production conditions to prevent cellular stress and protein aggregation.

• Counterbalance Statements: Lowering the expression temperature enhances protein solubility and slows down cell processes, reducing transcription, translation, cell division, and protein aggregation.

Opportunities:

Amalgamation of Advanced Technologies with Protein Expression Unlocks the Growth Potential in the Upcoming Years

Mammalian expression systems for complex, post-translationally modified proteins, cell-free protein expression systems for rapid protein synthesis, gene editing tools, such as CRISPR-Cas9 for precise genome modifications, and protein engineering techniques to improve protein stability and function are examples of advanced technologies in protein expression. These technologies are useful as it allows researchers to more efficiently and controllably produce large quantities of highly specific and functional proteins for research and therapeutic applications.

• For instance, in April 2021, researchers at MIT University, described a new gene editing technology called CRISPRoff that allowed researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged. This was a simple tool that could silence the vast majority of genes at the same time without any damage to the DNA, with great deal of homogeneity and in a way that could be reversed.

The market is classified into product, expression system, workflow, application, end-user, and region.

Product

On the basis of product, the market is divided into kits and reagents, vectors, competent cells, and instruments. The kits and reagent segment is attributed to rule over the market as it is an essential part of every protein expression experiment and needs to be replenished frequently as researchers carry out multiple steps throughout the process, from cloning to purification.

• For instance, in May 2022, ProteoGenix had launched its XtenCHOTM Transient Expression System Kit for widespread use within the life science research community. This followed extensive testing and optimization by the ProteoGenix team. With the ability to perform superior protein folding and humanoid post-translational modifications, XtenCHOTM had proven to be ideal for the small and medium-scale production of monoclonal antibodies.

Expression System

Under expression system, the market is bifurcated into mammalian and non-mammalian expression systems. The non-microbial expression systems holds the largest protein expression market share. This is due to its significantly lower cost, faster growth rates, and ease of manipulation as compared to mammalian cell lines.

Application

Stemming from application, therapeutic, industrial, and research are the sub-segmentations of this market. The therapeutic segment is projected to dominate the market as therapeutic proteins are used to treat chronic diseases, such as cancer, diabetes, and neurological disorders. Therapeutic proteins are a major focus in drug research as it has benefits including high selectivity and less adverse effects than other drugs. This makes effective protein expression techniques necessary to manufacture these therapeutic proteins at scale.

• For instance, in May 2024, Radar Therapeutics, a new biotechnology firm, described the endogenous RNA editor that the company was trying to co-opt to produce therapeutic proteins in specific cells. ADAR, a protective enzyme in cells, made a small edit on double-stranded RNA to recognize it as its own, and was being combined with mRNA technology for disease treatment.

End-User

The market is pigeonholed into pharmaceutical and biotechnology companies, academic research, contract research organizations, and others, on the premise of end-user. The pharmaceutical and biotechnology companies segment is expected to govern the marker as there is a rising demand for therapeutic proteins, rising prevalence of chronic diseases, ongoing protein expression advancements, and widespread use of cultured cells.

• For instance, in June 2024, Syngene, a Biotechnology company, launched its new protein production and expression platform. This new platform streamlined clone selection and enhanced operational productivity. It also supported wide range of biomolecules, including monoclonal antibodies, bio specifics, and others. This versatility facilitated integration with both perfusion and fed-batch manufacturing process.

Region

Geographically, the market is catalogued into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

North America: This region has the biggest protein expression market share. This is due to the presence of major pharmaceutical and biotechnology companies, research and academic institutions, regulatory bodies, and the high prevalence of chronic diseases in this region.

• For instance, in April 2024, Northwestern Medicine investigators had developed a method to measure protein expression in an individual neuron, a discovery that would enable scientists to study how this process goes awry in disease. Neurons in the brain communicate primarily through chemical signals and disruption in neuronal communication could lead to disorders such as autism, Parkinson’s and Alzheimer’s disease.

Europe: This is the region, which has the fastest growing market. This is due to this region’s strong government support for biotechnology research, its well-established pharmaceutical sector, its increased focus on protein therapeutics, and its rising use for cancer therapy.

• For instance, in September 2024, Takara Bio Europe, a wholly owned subsidiary of Takara Bio Inc., announced the launch of the Shasta Single-Cell System. This cutting-edge, high-throughput NGS solution enabled protein expression and purification, and was a novel biomarker discovery in oncology research. This comprehensive system combined well-validated chemistries with user-friendly bioinformatics tools, allowing researchers to mine more genomic and transcriptomic information from a much greater number of cells than previously possible, all while reducing both time and costs.

Protein Expression Market Report Scope:

Segmentation:

By Product:

• Kits and Reagents
• Vectors
  • Mammalian Expression Vectors
  • Baculovirus Expression Vectors
  • Vaccina Vectors
  • Lentiviral Vectors
  • Others
• Competent Cells
  • Chemically Competent Cells
  • Electrocompetent Cells
• Instruments
  • Pipettes
  • Liquid Handling Systems
  • Water Baths
  • Others

By Expression System:

• Mammalian
  • CHO
  • HEK 293
  • Others
• Non-Mammalian
  • Bacterial
  • Insect
  • Yeast
  • Others

By Application:

• Therapeutic
• Industrial
• Research

By End User:

• Pharmaceutical and biotechnological companies
• Academic research
• Contract research organizations
• Others

By Region:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • U.K.
  • France
  • Russia
  • Italy
  • Spain
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • Indonesia
  • Malaysia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • Israel
  • South Africa
  • Rest of the Middle East & Africa

The key players operating in this sector are adopting strategies, such as using recombinant DNA technology, optimizing vectors, and using cell culture media for further market diversification. The companies operating in the market are Agilent Technologies, Inc., Bio-Rad Laboratories, Inc., Thermo Fisher Scientific Inc., Merck KGaA, New England Biolabs, and others.

Protein Expression Market Companies:

• Agilent Technologies, Inc.
• Bio-Rad Laboratories, Inc.
• Thermo Fisher Scientific Inc.
• Merck KGaA
• New England Biolabs
• Promega Corporation
• QIAGEN
• Takara Bio Inc.
• Oxford Expression Technologies Ltd
• DH Life Sciences, LLC.
• Sartorius AG
• Sino Biological, Inc.
• GenScript
• Syngene International Limited

View a Additional List of Companies in Protein Expression Market

• In April 2024, Expression Systems and Thomson collaborated to demonstrate how the combination of Expression Systems new ESF AdvanCD cell culture medium and Thomson Optimum Growth flasks offers an effective solution for scaling up protein production and expression, utilizing baculovirus and insect cell expression platforms. In addition to highly consistent cell growth, exceptional expression levels were observed between various flask sizes and culture volumes, providing confidence in a robust and scalable platform.
• In May 2023,  10x Genomics, Inc., a leader in single cell and spatial biology, announced the commercial availability of a new Visium CytAssist Gene and Protein Expression product to expand the breadth of the Visium CytAssist spatial analysis capabilities. This continued expansion of the Visium platform was a testament to strengthen the company’s innovation engine and demonstrated leadership in spatial biology.

Analyst View:

The expansion of the protein expression market is being driven by a number of factors, including the growing need for biopharmaceuticals, greater government funding, developments in biotechnology and artificial intelligence, the outsourcing of more clinical tasks, and the trend toward personalized medicine. Additionally, protein expression facilitates quick manufacturing, is economical, and can produce a variety of proteins, all of which contribute to the market's expansion.

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