Digital PCR Market Overview
Digital PCR Market was valued at US$ 646.4 Million in 2024 and is projected to grow at a CAGR of 34.00% to reach US$ 9275.2 Million by 2034.
Digital PCR Market (dPCR) is the third generation of PCR which helps in enabling the absolute quantification through partitioning of reaction. Digital PCR (dPCR) is highly sensitive and accurate in molecular detection. Digital PCR has determined the application like rare mutation detection, trace DNA detection, and copy number variation. Digital PCR helps in enabling precise and highly sensitive quantification of nucleic acids. The technique is called as ‘Digital PCR’ because reaction will be ‘1’ or will not be ‘0’ which generates fluorescent signal. Number of target molecules present on array is divided by dilution factor for giving the target DNA concentration of original sample. Traditional PCR determines the amount of amplified PCR product at end of several PCR cycles. Digital PCR helps in measuring the number of target molecules by directly counting the positive fluorescence in compartments. Digital PCR takes about 3 to 5 days after drop off of sample. Digital PCR is different from conventional PCR because it counts the target molecules directly in digital format without relying on standards or endogenous controls. Digital PCR test is performed by diluting assay mixture and sample into thousands of small compartments. Dilution is performed so that target molecule concentration in each reaction can be assumed safely as zero or one. Thermal cycling is carried out at end point. Compartments that contains target molecule shows fluorescence while compartment which do not contains target molecules shows only background fluorescence. Reaction with target molecule is counted as one or called as PCR-positive reaction while the reaction without target molecule is counted as zero or called as PCR-negative reactions. After counting complete set of reactions number of target molecules in entire reaction volume is equal to the number of positive reactions which is counted. Thus, the absolute target concentration is then calculated by dividing the total number of target molecules by total volume. However rising prevalence of diseases has given positive impact on target market growth.
Digital PCR Market Dynamics
Rising prevalence of disease and rate of urbanization is one of the leading factors for the Digital PCR Market growth. Urbanization has given rise in consumption of western food, processed food, frozen packed foods, which are unhealthy and affected the health of human being. Urbanization has given rise in disposable income which allows the individual to enhance their lifestyle, consuming high amount of red meat and animal derived food, fats & oils, sugar, sodium, alcohol intake, smoking which has affected the health and has given rise in prevalence of disease. Urbanization has caused change in diet, water pollution, air pollution due to increased number of vehicles and residential population. Urbanization has affected health condition due to emergence of infectious diseases, pollution related health conditions, inadequate house condition and consumption of poor nutrition food. Due to rapid urbanization there is rise in overcrowded settlements, inadequate housing conditions, and lack of infrastructure for water and sanitation which has caused higher risk of infectious diseases. Inadequate hygiene at fast food stalls, rising consumption of unhealthy fast food has given rise in infectious diseases. For example, Typhoid and Cholera are transmitted through water and food contaminated with human faeces which contains pathogen Urbanization has given rise in emergence and spread of arboviral disease like Zika virus, Chikungunya, Dengue which are highly adapted in urban areas. Highly connected urban areas and dense areas has become major hotspot in outbreak of disease like SARS and COVID-19. Digital PCR used in analyzing expression of gene at DNA and RNA levels. Digital PCR is used in detecting and measuring genomic DNA methylation, and increase sensitivity in transcriptional analyses with absolute quantification. Digital PCR is used in detecting diseases with higher accuracy. According to data published by United Nations in 2018, about 55% of the world’s population resided in urban areas, and it is projected that this percentage will increase over the forecast period. However, the growth in prevalence of disease and population in urban areas boosts the demand for Digital PCR market.
Wide applications and advantages
Wide applications and advantages has become the major factor in target market growth. Digital PCR has many advantages like – Small volume of sample, in which Digital PCR achieves high accuracy even if small volume of sample is available. Digital PCR is performed based on minimum of sample, and reaping reliable results thus, by eliminating error which is generated from pre-amplification. High sensitivity & absolute quantification – As compared to Real time fluorogenic quantitative PCR, Digital PCR is more sensitive and applicable clinically. In Digital PCR standard PCR system is accomplished by various micro-units which increase largely the tolerance of PCR system to inhibitors. Digital PCR achieves sensitivity up to 0.1%, by making it ideal tool for rare mutation detection, tracing DNA detection, circulating tumor DNA detection, etc. Digital PCR has been modified technologically in a tool making it more operable and compatible, and thus, its two-dimensional data is highly readable. Independence on amplification efficiency & high repeatability of results - Digital PCR realize absolute quantification as it defines amplification results with ‘1’ and ‘0’ & therefore, quantifies results with counts, which makes possible absolute quantification. Digital PCR can retest the results of NGS – Digital PCR helps in calculating the expression of nucleic acids with end-point signals, and therefore its results rule out interference of unstable amplification & becomes highly repeatable with below 5% error rate, and lowers mispairing of target sequences. Digital PCR can be combined with NGS for quantifying and interpreting the data, and retest the results of NGS. In Digital PCR quality of sequencing data is guaranteed by including joint dimer, adaptors, long fusion junction, error like fragment, etc. However, Digital PCR suppresses former techniques in every aspects.
Droplet Digital PCR has wide applications like – in gynecological tumor, it has shown high con-cordance with traditional techniques and detect absolute copy number of HER2 in invasive breast cancer, second generation sequencing, far outdoing semi-quantitative PCR, and hybrid chip technologies. Digital PCR is transformed and widely used in obstetrics. Autosomal recessive disorder - Digital PCR can detect beta-thalassemia in case of maternal and paternal mutation, by quantifying maternal mutated DNA & fetal mutated DNA help in diagnosing the fetus inheriting pathogenic genes. For instance in 2012 (PMC), based on reformed relative mutation dosage and paternal haplotypes, Lam et al designed the probes for globulins & external SNP to pinpoint site of interest, digital PCR was performed for identifying genotype of fetus, and consequently two families of beta-thalassemia were screened out. Digital PCR has wide applications in clinical use for non-invasive prenatal testing, chromosomal aneuploidy detection, autosomal recessive disorder, gynecological tumor, HR-positive breast cancer, triple negative breast cancer, cervical cancer, etc. However, wide applications and various advantages of Digital PCR has fueled the target market growth.
Restrains:
There are some disadvantages of digital PCR like technical limitations, cross-contamination, taylor diffusion, measures only partitions that are successfully undergoes amplification. However, expensive cost and some disadvantages of digital PCR may somewhat restrain the target market growth.
Digital PCR Market Segmentation
The Digital PCR market is segmented based on type, product, end-users and region.
On the basis of type, the Digital PCR market is segmented into Chip Based Digital PCR, Droplet Digital PCR, Beaming Digital PCR. On the basis of product, the target market is segmented into Instruments, Consumables & Reagents, Software & Services. On the basis of end-users, the target market is segmented into Hospitals, Clinics, Diagnostic Centers, Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, and others.
Regional Insights:
On region the Digital PCR Market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. The North America market is estimated to witness a significantly high revenue share over the forecast period, owing to growing population, especially in countries such as Europe and Asia Pacific, and technological advancements. Moreover, rising prevalence of disease, well developed & robust healthcare and research infrastructure, advanced technological development, government initiative, and rising adoption of digital PCR over traditional PCR, is anticipated to increase demand for Digital PCR in the region.
Report Scope:
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Attribute |
Details |
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Base year for estimation |
2023 |
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Forecast period |
2024 – 2034 |
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Market representation |
Revenue in USD Million & CAGR from 2024 to 2034 |
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Market Segmentation |
By Type - Chip Based Digital PCR, Droplet Digital PCR, Beaming Digital PCR By Product – Instruments, Consumables & Reagents, Software & Services By End-Users - Hospitals, Clinics, Diagnostic Centers, Pharmaceutical & Biotechnology Companies, Academic & Research Institutes, and others
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Regional scope |
North America - U.S., Canada Europe - UK, Germany, Spain, France, Italy, Russia, Rest of Europe Asia Pacific - Japan, India, China, South Korea, Australia, Rest of Asia-Pacific Latin America - Brazil, Mexico, Argentina, Rest of Latin America Middle East & Africa - South Africa, Saudi Arabia, UAE, Rest of Middle East & Africa |
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Report coverage |
Revenue forecast, company share, competitive landscape, growth factors, and trends |
Segments Covered in the Report:
This report forecasts revenue growth at global, regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2022 to 2032. For the purpose of this study, has segmented the Digital PCR Market report based on type, product, end-users, and region:
Digital PCR Market, By Type:
- Chip Based Digital PCR
- Droplet Digital PCR
- Beaming Digital PCR
Digital PCR Market, By Product:
- Instruments
- Consumables & Reagents
- Software & Services
Digital PCR Market, By End-Users:
- Hospitals
- Clinics
- Diagnostic Centers
- Pharmaceutical & Biotechnology Companies
- Academic & Research Institutes
- Others
Digital PCR Market, By Region:
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- North America
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- U.S.
- Canada
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- Europe
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- Germany
- UK
- France
- Russia
- Italy
- Rest of Europe
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- Asia Pacific
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- China
- India
- Japan
- South Korea
- Rest of Asia Pacific
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- Latin America
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- Brazil
- Mexico
- Rest of Latin America
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- Middle East & Africa
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- GCC
- Israel
- South Africa
- Rest of Middle East & Africa
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- North America
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Digital PCR Market Key Players
The key players operating the Digital PCR Market includes, Thermo Fisher Scientific Inc., F. Hoffman-La Roche Ltd., Bio-Rad Laboratories Inc., Merck KGaA, Stilla Technologies, QIAGEN, JN Medsys, Avance Biosciences, Snibe Co. Ltd., Standard BioTools Inc., and others.
Digital PCR Market Key Issues Addressed
Recent Development:
- In August 2022, Roche has launched a new digital PCR system ‘Digital LightCycler System’ a powerful diagnostic platform to fight against cancer & other diseases. Newly launched Digital LightCycler System’ is a next generation digital PCR system which will help clinical researchers to better understand the nature of patients genetic disease, cancer disease or infection. Newly launched system has ability to find and quantify ultra-rare, hard to detect mutations by leading to early diagnosis & treatment strategies. Newly launched system is designed for laboratories to perform precise and highly sensitive DNA & RNA analysis in oncology and infectious disease.
- In September 2022, Thermo Fisher Scientific Inc., has launched World’s first fully integrated ‘QuantStudio Absolute Q’ Digital PCR System. QuantStudio Absolute Q’ Digital PCR System is ideal for cell & gene therapy development, oncology and other research applications. Newly launched system is designed for providing highly accurate and consistent results within 90 minutes. Newly launched system uses microfluidic array technology & simplified workflows. It is designed for improving data accuracy & consistency, and minimize the risk of user error.
Digital PCR Market Company Profile
- Thermo Fisher Scientific*
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- F. Hoffman-La Roche Ltd.*
- Bio-Rad Laboratories Inc.
- Merck KGaA
- Stilla Technologies
- QIAGEN
- JN Medsys
- Avance Biosciences
- Snibe Co. Ltd.
- Standard BioTools Inc.
“*” marked represents similar segmentation in other categories in the respective section
Digital PCR Market Table of Contents
- Research Objective and Assumption
- Preface
- Research Objectives
- Study Scope
- Years Considered for the study
- Assumptions
- Abbreviations
- Research Methodology
- Research data
- Primary Data
- Primary Interviews
- Primary Breakdown
- Key data from Primary Sources
- Key Thickness Insights
- Secondary Data
- Major Secondary Sources
- Secondary Sources
- Market Estimation
- Top-Down Approach
- Approach for estimating Market Share by Top-Down Analysis (Supply Side)
- Bottom-Up Approach
- Approach for estimating market share by Bottom-up Analysis (Demand Side)
- Market Breakdown and Data Triangulation
- Research Assumptions
- Market Purview
- Executive Summary
- Key Findings—Global Outlook for medical carts Strategies
- Key Questions this Study will Answer
- Market Snippet, By Type
- Market Snippet, By Product
- Market Snippet, By End-Users
- Market Snippet, By Region
- Opportunity Map Analysis
- Executive Summary—3 Big Predictions
- Market Dynamics, Regulations, and Trends Analysis
- Market Dynamics
- Drivers
- Restrains
- Market Opportunities
- Market Trends
- DR Impact Analysis
- PEST Analysis
- Porter’s Five Forces Analysis
- Opportunity Orbit
- Market Investment Feasibility Index
- Macroeconomic Factor Analysis
- Market Dynamics
- Digital PCR Market, By Type
- Overview
- Market Value and Forecast (US$ Mn), and Share Analysis (%), 2022 – 2032
- Y-o-Y Growth Analysis (%), 2022 – 2032
- Segment Trends
- Chip Based Digital PCR
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Droplet Digital PCR
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Beaming Digital PCR
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Overview
- Digital PCR Market, By Product, 2022 – 2032, (US$ Mn)
- Overview
- Market Value and Forecast (US$ Mn), and Share Analysis (%), 2022 – 2032
- Y-o-Y Growth Analysis (%), 2022 – 2032
- Segment Trends
- Instruments
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Consumables & Reagents
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Software & Services
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Overview
- Digital PCR Market, By End-Users, 2022 – 2032, (US$ Mn)
- Overview
- Market Value and Forecast (US$ Mn), and Share Analysis (%), 2022 – 2032
- Y-o-Y Growth Analysis (%), 2022 – 2032
- Segment Trends
- Hospitals
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Clinics
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Diagnostic Centers
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Pharmaceutical & Biotechnology Companies
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Academic & Research Institutes
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Others
- Overview
- Market Size and Forecast (US$ Mn), and Y-o-Y Growth (%), 2022 – 2032
- Overview
- Digital PCR Market, By Region, 2022 – 2032, (US$ Mn)
- Overview
- Market Value and Forecast (US$ Mn), and Share Analysis (%), 2022 – 2032
- Y-o-Y Growth Analysis (%), 2022 – 2032
- Regional Trends
- North America
- Market Size and Forecast (US$ Mn), By Type, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Product, 2022 – 2032
- Market Size and Forecast (US$ Mn), By End-Users, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Country, 2022 – 2032
- U.S.
- Canada
- Europe
- Market Size and Forecast (US$ Mn), By Type, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Product, 2022 – 2032
- Market Size and Forecast (US$ Mn), By End-Users, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Country, 2022 – 2032
- UK
- France
- Germany
- Russia
- Italy
- Rest of Europe
- Asia Pacific
- Market Size and Forecast (US$ Mn), By Type, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Product, 2022 – 2032
- Market Size and Forecast (US$ Mn), By End-Users, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Country, 2022 – 2032
- India
- Japan
- South Korea
- China
- Rest of Asia Pacific
- Overview
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- Latin America
- Market Size and Forecast (US$ Mn), By Type, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Product, 2022 – 2032
- Market Size and Forecast (US$ Mn), By End-Users, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Country, 2022 – 2032
- Latin America
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-
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- Brazil
- Mexico
- Rest of Latin America
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- Middle East & Africa
- Market Size and Forecast (US$ Mn), By Type, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Product, 2022 – 2032
- Market Size and Forecast (US$ Mn), By End-Users, 2022 – 2032
- Market Size and Forecast (US$ Mn), By Country, 2022 – 2032
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- GCC
- Israel
- South Africa
- Rest of Middle East
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- Competitive Landscape
- Heat Map Analysis
- Market Presence and Specificity Analysis
- Company Profiles
- Thermo Fisher Scientific Inc.
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- F. Hoffman-La Roche Ltd.
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Bio-Rad Laboratories Inc.
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Merck KGaA
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Stilla Technologies
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- QIAGEN
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- JN Medsys
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Avance Biosciences
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Snibe Co. Ltd.
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- Standard BioTools Inc.
- Company Overview
- Product Portfolio
- Key Highlights
- Financial Performance
- Business Strategies
- The Last Word
- Future Impact
- About Us
- Contact
FAQs
The Digital PCR Market is segmented into type, product, end-users, and region.
Digital PCR Market is driven by factors like rising prevalence of disease, rate of urbanization, wide applications and advantages.
By region, the Digital PCR market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. The North America market is estimated to witness a significantly high revenue share over the forecast period, owing to growing population, especially in countries such as Europe and Asia Pacific, and technological advancements.
The key players operating the Digital PCR Market includes, Thermo Fisher Scientific Inc., F. Hoffman-La Roche Ltd., Bio-Rad Laboratories Inc., Merck KGaA, Stilla Technologies, QIAGEN, JN Medsys, Avance Biosciences, Snibe Co. Ltd., Standard BioTools Inc., and others.