DNA Synthesis Market Size, Share, By Services, Application, End-User, and By Region - Trends, Analysis and Forecast till 2035

• DNA synthesis market size is expected to grow at USD 19.4 billion by 2035.
• The target market was worth USD 4.57 billion in 2024.
• Target market is expected to grow at a CAGR of 17.2%.

DNA synthesis is the natural or artificial creation of deoxyribonucleic acid (DNA) molecules. The market is expected to grow due to the increasing demand for DNA synthesis owing to its applications in molecular biology, genetic engineering, and clinical diagnostics & therapeutics. In addition, the growing demand for research in drug discovery and personalized medicine are another factors propelling growth of the global market. Furthermore, technological advancements, which increases the efficiency and cost-effectiveness of production is also anticipated to create opportunities for growth of the global market over the forecast period.

Key Takeaways:

• The Services segment intimidated the market as a result of focus on genomics research, personalized medicines, and others. On that account, many scientific managers are aiming more on sustainable manufacturing of innumerable services to delivered efficiency.
• For instance, in October 2024, Philipp Markolin, scientific marketing manager at peptide and oligonucleotide manufacturers Bachem, shares his insights on the latest innovations in sustainable oligonucleotide manufacturing to boost efficiency and reduce waste.

Key Drivers of Target Market:

Rising Usage of DNA Synthesis in R&D Sector Can Drive Market Expansion

Rising use of DNA synthesis in various R&D activities contributes to DNA synthesis market growth. Synthetic DNA is used as controls and standards in DNA sequencing experiments to validate the accuracy of the sequencing process. DNA probes is used in various diagnostic techniques, such as fluorescence in situ hybridization (FISH) or polymerase chain reaction (PCR).  Additionally, DNA synthesis is also used to create synthetic genes that encode antigens for the development of vaccines. Thus, many scientist are focusing more on DNA synthesis to conduct R&D activities.

• For instance, in April 2024, Ribbon Biolabs, has shown remarkable potential in its mission to provide unmatched solutions to the synthesis of complex DNA. The ability to precisely and accurately synthesize DNA unlocks a range of possibilities, offering a canvas for scientists to engineer, manipulate, and reimagine biological systems to study and treat disease. This provides scientists with the tools to facilitate unprecedented discoveries and transformative breakthroughs.

Restraints:

High Cost of DNA Synthesis can Hamper Target Market Expansion

Synthesizing long DNA sequences can be costly, particularly when high accuracy and complexity are required. The cost of oligonucleotide synthesis can increase significantly as the length and complexity of the DNA sequence grows. Expensive chemical reagents & equipment, complexity & length of sequences, and error correction & quality control are some of the factors that contribute to the expenses.

• Counterbalance Statements: One of the major solutions to this problem are improving synthesis technology, optimizing DNA design & sequence engineering, reducing reagent costs, and among others.

Opportunities:

New Innovations and Technological Advancements to Augment Market Growth

Enzymatic synthesis of DNA is at the beginning of its technology lifecycle arc. There is tremendous progress to be made in the commercial implementation of this technology. Novel hardware, de novo enzymatic synthesis, and high performance enzymes with long shelf-life, are all part of the future development of enzymatic DNA synthesis.

• For instance, in March 2023, Ansa Biotechnologies, Inc., a pioneer of next-generation DNA synthesis, announced the successful de novo synthesis of the world’s longest DNA oligonucleotide ever reported to be produced in a single synthesis. The “Ansamer” oligonucleotide was cloned using standard molecular biology techniques and found to contain approximately 28% sequence-perfect molecules, indicating an industry-leading average stepwise yield of approximately 99.9% during its synthesis.

The market is segmented based on services, application, end-user, and region. 

Services

On the basis of services, the DNA synthesis market is segmented into oligonucleotide synthesis, custom oligonucleotide synthesis, gene synthesis, and others. Gene synthesis dominate the target market growth due to its high demand as it allows researchers and industries to customize DNA sequences for specific needs. 

• For instance, in November 2023, Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced the launch of Twist Express Genes, a new leading gene synthesis service with an order to shipping turnaround time of five to seven business days.

Application

The DNA synthesis market by application is categorized into research & development, diagnostics, and therapeutics. The research & development segment holds the largest DNS synthesis market share due to the growing use of DNA synthesis in research studies, particularly in the fields of molecular biology, genetic testing, and drug discovery.

End-User

On the basis of end-user, the DNA synthesis market is divided into biopharmaceutical companies, academic & research institutes, contract research organizations. Biopharmaceutical companies are expected to dominate the target market growth during the forecast period due to their investments in R&D sector.

• For instance, in October 2024, Twist Bioscience Corporation, a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, announced it has entered into a royalty purchase agreement with XOMA Royalty Corporation, the biotech royalty aggregator.

Regional

Geographically, the market is studied across North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

North America: North America is expected to dominate the growth of the market during forecast period. The growth is attributed to the significant research funding for DNA synthesis technologies, advanced healthcare infrastructure, robust medical facilities, presence of key biotech companies, increasing cases of chronic and genetic diseases, and among others.

• For instance, in April 2024, with the announcement of a USD 500,000 donation to the UCSC Genomics Institute in support of the UCSC Paleogenomics Lab, Colossal continues to expand its ancient DNA academic collaborations to drive understanding of climate migration, evolutionary modification, and ecosystem redundancy.

Asia Pacific: Asia Pacific is considered to be the fastest growing region in the target market as countries such as India, China, and many more are leading the charge significantly due to rising government support, increasing collaboration between academic institutes & key players to expand synthetic DNA technologies, rising awareness regarding personalized medicines, and increasing number of skilled scientists, among others.

DNA Synthesis Market Report Scope:

Segmentation:

By Services:

• Oligonucleotide Synthesis
• Custom Oligonucleotide Synthesis
• Gene Synthesis
• Others

By Application:

• Research & Development
• Diagnostics
• Therapeutics

By End User:

• Biopharmaceutical Companies
• Academic & Research Institutes
• Contract Research Organizations

By Region:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • U.K.
  • France
  • Russia
  • Italy
  • Spain
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • Indonesia
  • Malaysia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • Israel
  • South Africa
  • Rest of Middle East & Africa

The key players operating in the DNA synthesis market are GenScript, SYNBIO TECHNOLOGIES, Thermo Fisher Scientific Inc., DNA TwoPointO, Inc., Gene Universal, Inc., and among Others. To expand their product portfolio and dominate the market, these key players are adopting strategies, such as mergers and acquisitions, partnerships and agreements, and new product launches and approval.

List of Key Players in the Market:

• GenScript
• SYNBIO TECHNOLOGIES
• Thermo Fisher Scientific Inc.
• DNA TwoPointO, Inc.
• Gene Universal, Inc.
• Elegen Corporation
• Evonetix
• TWIST BIOSCIENCE
• Integrated DNA Technologies, Inc.
• Biomatik
• Ansa Biotechnologies
• 4basebio
• Camena Bioscience
• AZENTA LIFE SCIENCES

• In December 2023, EVONETIX LTD, the company developing semiconductor scale technology to improve access to gene synthesis, announced the signing of a joint development agreement and commercial supply agreement with Analog Devices, Inc., a global semiconductor leader. This agreement signals the continuation of the long-standing combined work of both companies, bringing efforts to the next stage in producing a new technology benchmark that will help meet the global demand for better gene synthesis.
• In October 2023, EVONETIX LTD, the Company developing semiconductor scale technology to improve access to gene synthesis, announced its first placement of a DNA synthesis development platform for evaluation at Imperial College London. This is the Company’s first platform to be installed in an external scientific setting, which is a significant milestone as it continues to optimize its gene synthesis technology in preparation for customer use and commercialization.

Analyst View:      

The industry for DNA synthesis market is expected to witness substantial growth due to the increasing demand for DNA synthesis due to its applications in molecular biology, genetic engineering, and clinical diagnostics & therapeutics, and the growing demand for research in drug discovery and personalized medicine. New innovations and development, advanced technologies, along with several collaborations and partnerships help to boost the growth of the market in upcoming years.

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