Proteinase K Market By Type (Natural Proteinase K and Recombinant Proteinase K), By Physical Form (Liquid and Powder), By Application (Nucleic Acids Isolation, Mitochondria Isolation, Endotoxin Removal, Polymerase Chain Reaction (PCR), Real-Time (RT) PCR, and Others), By End User (Bio-Pharmaceutical Companies, Pharmaceutical Companies, Academic & Research Centres, and Contract Research Organization), and By Region – Global Forecast till 2029

Proteinase K is a subtilisin-related serine protease broad spectrum with great particular activity. It is capable of digesting keratin, which is a hair protein, hence the name, Proteinase K. Proteinase K splits the top part of the peptide bond adjacent to the carboxyl group and aromatic amino acids present in the protein. It is generally used in molecular biology to digest protein and take out the impurities from preparations of nucleic acids. It is used for the wrecking of proteins in cell lysates such as tissue, and cell culture cells. Also, it helps in releasing the nucleic acid and purification of the genomic DNA from the bacteria. It is active in a broad spectrum of temperatures. A pH between 7.5- 12 with a temperature between 20°C- 60°C, it buffers with an optimal activity. Global Proteinase K market is continuously witnessing positive development paying to more significant research & development tasks and investing in research institutes, pharmaceutical companies, and biopharmaceutical companies for innovation.

Increasing prevalence of chronic diseases

According to a World Health Organisation report, the burden of chronic diseases is rapidly increasing worldwide. The growth of the proteinase K market is mainly uplifted by the expanding prevalence of chronic diseases. It has been calculated that, in 2001, chronic diseases contributed approximately 60% of the 56.5 million total reported deaths in the world and approximately 46% of the global burden of disease.

Increasing demand for gene therapy

According to Gene Therapy Net, Glybera (Alipogene tiparvovec) is a gene therapy treatment designed to reverse lipoprotein lipase deficiency (LPLD), a rare inherited disorder that can cause severe pancreatitis. In July 2012, the European Medicines Agency (EMA) recommended it for approval and the recommendation was endorsed by the European Commission in November 2012. With this, stability and low production cost of proteinase K are estimated to rise global proteinase K market over the forecast period.

However, the availability of other proteases is expected to hinder the growth of the global proteinase K market. There are various substitutes available for proteinase K such as pepsinogen, which is also a broad-spectrum protease and possesses less specific activity than proteinase K. For instance, Nagarse is another substitute for proteinase K and is less costly than proteinase K.

Global proteinase K market is segmented based on type, physical form, application, end user, and by region.

Depending upon the type, the global proteinase K market is categorized into Natural Proteinase K and, Recombinant Proteinase K. Depending upon the physical form, the global market is categorized into liquid and powder. Depending upon the application, the target market is categorized into nucleic acids isolation, mitochondria isolation, endotoxin removal, polymerase chain reaction (PCR), real-time (RT) PCR, and others.  Depending upon the end user, the target market is categorized into Bio-pharmaceutical companies, pharmaceutical companies, academic and research centers, and contract research organizations.

Regional Insights:

Regionally, the overall industry is divided into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. The North America proteinase K market held a dominant position in 2019. In terms of value, it was followed by Europe. Asia Pacific is expected to witness positive growth owing to increased governmental funding for research in the life science sector, increasing demand for biological products, and the rising presence of biopharmaceutical companies in the region.

Report Scope:

Segments Covered in the Report:

This report predication revenue growth at global, regional, and country levels and serves as the analysis of the recent trends and opportunities in each of the sub-segments from 2020 to 2027.  This study has segmented the global proteinase K market report based on type, physical form, application, end-user, and region.

Based on the Type, the Global Proteinase K market is segmented as: 

• Natural Proteinase K
• Recombinant Proteinase K

Based on the Physical Form, the global Proteinase K market is segmented as:

• Powder
• Liquid

Based on the Applications, the global Proteinase K market is segmented as:

• Nucleic Acids Isolation
• Mitochondria Isolation
• Endotoxin Removal
• Polymerase Chain Reaction (PCR) and Real-Time PCR (RT)
• Other0

Based on an End User, the global Proteinase K Market is segmented as:

• Bio-Pharmaceutical Companies
• Pharmaceutical Companies
• Academic and Research Center’s
• Contract Research Organization 

Global Proteinase K market, By Region:

• • • North America
      • • The U.S.
        • Canada
    • Europe
      • • Germany
        • UK
        • France
        • Russia
        • Italy
        • Rest of Europe
    • Asia Pacific
      • • China
        • India
        • Japan
        • South Korea
        • Rest of Asia Pacific
    • Latin America
      • • Brazil
        • Mexico
          Rest of Latin America
    • Middle East & Africa
      • • GCC
        • Israel
        • South Africa
        • Rest of Middle East & Africa

The key players operating in the global proteinase K market include Merck KGaA, Codexis, Inc., F. Hoffmann-La Roche Ltd., Amano Enzyme Inc., Advanced Enzymes Technologies Ltd., Biocatalysts Ltd., Amicogen, Dyadic International, BBI Solutions, Affymetrix and American Laboratories. Key players are undertaking various strategies to expand their market presence. For instance, in June 2020, Codexis, Inc., a leading protein engineering company and developer of high-performance enzymes, and Alphazyme LLC, an emerging leader in the development and manufacture of nucleic acid metabolizing enzymes, announced a co-marketing & enzyme supply collaboration agreement for the production and co-marketing of enzymes for life science applications.

• Merck KGaA,
  • Company Overview
  • Product Portfolio
  • Key Highlights
  • Financial Performance
  • Business Strategies
• Codexis, Inc.
• F. Hoffmann-La Roche Ltd.
• Amano Enzyme Inc.
• Advanced Enzymes Technologies Ltd.
• Biocatalysts Ltd.
• Amicogen
• Dyadic International
• BBI Solutions
• Affymetrix
• American Laboratories