Protein Purification and Isolation Market, By Technology (Ultrafiltration, Precipitation, Preparative Chromatography Techniques, Electrophoresis, and Western Blotting), By Application (Drug Screening, Protein-Protein Interaction Studies, Biomarker Discovery, Target Identification, Protein Therapeutics, and Disease Diagnostics and Monitoring), By Product (Instruments, Consumables, and Others), By End User (Academic Medical Institutes, Hospitals and Diagnostic Centers, Pharmaceutical and Biotechnology Companies, and CROs) and By Region (North America, Europe, Asia Pacific, Latin America, And Middle East & Africa) - Trends, Analysis and Forecast Till 2034

Protein Purification and Isolation Market was valued at US$ 7.8 Billion in 2024 and is projected to grow at a CAGR of 11.20% to reach US$ 22.5 Billion by 2034.

Isolation, separation, and purification refer to techniques used to isolate, concentrate, or purify cells, viruses, cell fractions, organelles, or biological macromolecules, for example, proteins, protein complexes, chromatin, nucleic acids, carbohydrates, or lipids. These procedures are essential for protein studies, which isolate, concentrate, stabilize, and remove impurities such as nucleic acids, endotoxins, and viruses. It involves determining the starting materials and maintaining a purification table to track the progress of the enzyme. The goal of the protein purification process is to isolate large amounts of useful proteins with very few contaminants. This method separates the protein and non-protein components of the mixture to break down the desired protein. Characterization of function, structure modeling, and protein binding research are beneficial. Technological innovations have led to new avenues in protein purification and isolation technology. Protein Purification A common first step for protein isolation is precipitation with ammonium sulfate (NH4)2SO4. This is done by adding rising amounts of ammonium sulfate and collecting different fractions of precipitated proteins, then, the ammonium sulfate can be removed using dialysis.  The principle of protein purification is Different proteins have different amino acid sequences and spatial structures, which result in differences in their physical, chemical, and biological properties. Increasing demand for rapid purification kits to rapidly screen, prepare, purify, and condense protein samples and expanding research in the pharmaceutical and biotechnology industries are the primary growth drivers for the growth of the protein purification and isolation market.

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Increased research in the pharmaceutical and biotechnological fields & high cost of purification instruments

Key factors contributing to the growth of the protein purification and isolation market include factors increasing the importance of identifying new ligands paradigm shift towards automated equipment for protein purification. Additionally, increasing growth of the proteomics market, increased research in the pharmaceutical and biotechnological sectors, and also increasing need to identify novel ligands are fueling the growth of the protein purification and isolation market. Rapid purification kits to rapidly screen, prepare, purify and concentrate protein samples help target market growth. R&D technological advancements such as single-use purification technology and increased funding from both public and private for increasing research in the field of structure-based drug design are driving the growth of the market. However, high cost of purification tools and lack of skilled professionals are the factors hindering the growth of the market. The growing need to identify new ligands for drug discovery processes and the demand for protein therapeutics create opportunities in the target market.

Technological advancement

Manufactures involved in Bio-Polyamide Market are developing advanced versions of their products due to new age technological advancements. Preparative chromatography techniques are mainly used for protein purification and separation and are expected to show significant growth over the forecast period. Chromatography is one of the most accurate and sensitive techniques compared to other tests. The protein purification market during the forecast period is driven by the presence of a large number of protein purification players, established research and development infrastructure, and technological advancements in the field of proteomics. In January 2022, Insect protein isolation technique reveals nutritional benefits of powders. A team of US researchers is laying the groundwork for developing an efficient protein isolation technique for insects, a team of US researchers is laying the groundwork for developing an efficient protein isolation technique for insects, a process that allows for the purification and enhanced concentration of proteins from a variety of sources.

The protein purification and isolation market is segmented based on technology, application, product, end user, and region.

Protein Purification and Isolation Market, By Technology

Based on technology, the protein purification and isolation market is segmented into Ultrafiltration, Precipitation, Preparative Chromatography Techniques, Electrophoresis, and Western Blotting Ultrafiltration, Precipitation, Preparative Chromatography Techniques, Electrophoresis, and Western Blotting. Preparative chromatography is further divided into ion exchange chromatography, affinity chromatography, reversed-phase chromatography, hydrophobic interaction chromatography and size exclusion chromatography. Among these, affinity chromatography is further classified into immobilized metal ion chromatography, immunoaffinity chromatography and bead-based chromatography. Electrophoresis is further divided into gel electrophoresis, isoelectric focusing and capillary electrophoresis. Chromatography segment is the largest revenue holder and is expected to grow significantly during the forecast period. Chromatography is one of the most accurate and sensitive methods for separating and purifying proteins. As a result, many businesses are focusing on commercializing fresh products produced on this technology to diversify their product lines.

Protein Purification and Isolation Market, By Application

Based on the application, the target market is segmented into Drug Screening, Protein-Protein Interaction Studies, Biomarker Discovery, Target Identification, Protein Therapeutics, Disease Diagnostics and Monitoring. Protein-protein interaction network (PIN) is a useful tool for the systematic investigation of complex biological activities in the cell. With increasing interest in proteome-wide interaction networks, PINs have been reconstructed for many species, including viruses, bacteria, plants, animals, and humans.

Protein Purification and Isolation Market, By Product

Based on product, the market is classified into instruments, consumables and others. The consumables are further classified into protein purification kits, reagents, prepacked columns, protein purification resins, and magnetic beads, and others. In this the magnetic beads is further segmented into tagged magnetic beads, and non-tagged magnetic beads.

Protein Purification and Isolation Market, By End User

Based on end user, the target market is bifurcated into Academic Medical Institutes, Hospitals and Diagnostic Centers, Pharmaceutical and Biotechnology Companies, and CROs. Academic medical institutions are gaining more acceptance in the end-user segment as academic institutions have a larger market share compared to other segments. As academic research institutions focus more on research and studies related to protein structure and function and their identification along with isolation, detailed kinetic analysis and protein-protein interactions are the processes that are driving the growth of the protein purification and isolation market during the forecast period.

Regional Insights:

On region the Protein Purification and Isolation Market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.

The North American market is expected to account for the highest revenue share in the protein purification market due to the presence of large number of protein purification market players. In addition, developed research and development infrastructure and technological advances in the field of proteomics. On the other hand, Asia Pacific is expected to experience the fastest growth rate in the coming years, largely due to rising investments in emerging countries.

Report Scope:

Segments Covered in the Report:

This report forecasts revenue growth at , regional, and country levels and provides an analysis of the latest industry trends and opportunities in each of the sub-segments from 2024 to 2034. For the purpose of this study, has segmented the Protein Purification and Isolation Market report based on technology, application, product, end user and region:

Protein Purification and Isolation Market, By Technology:

• Ultrafiltration
• Precipitation
• Preparative Chromatography Techniques
• Electrophoresis
• Western Blotting

Protein Purification and Isolation Market, By Application:

• Drug Screening
• Protein-Protein Interaction Studies
• Biomarker Discovery
• Target Identification
• Protein Therapeutics
• Disease Diagnostics
• Monitoring

Protein Purification and Isolation Market, By Product:

• Instruments
• Consumables
• Others

Protein Purification and Isolation Market, By End User:

• Academic Medical Institutes
• Hospitals and Diagnostic Centers
• Pharmaceutical and Biotechnology Companies
• CROs

Protein Purification and Isolation Market, By Region:

• North America
  • Middle East & Africa
    • GCC
    • Israel
    • South Africa
    • Rest of Middle East & Africa
• Latin America
  • Brazil
  • Mexico
  • Rest of Latin America
• Asia Pacific
  • China
  • India
  • Japan
  • South Korea
  • Rest of Asia Pacific
• Europe
  • Germany
  • UK
  • France
  • Russia
  • Italy
  • Rest of Europe
• U.S.
• Canada

The key players operating the Protein Purification and Isolation Market includes

• Thermo Fisher Scientific is a large, well-known company that sells good products and is a market leader. Thermo Fisher Scientific provides industry leading pharma services solutions for drug development, clinical trial logistics and commercial manufacturing.
• Merck Millipore Tagged offers an extensive portfolio of affinity purification tools for recombinant protein, antibody purification, nucleic acid purification, protein-protein interaction studies and albumin depletion. Merck's complete range of reagents and enzymes for cell lysis and protein extraction provides a wide range of options to put together the perfect extraction protocol for specific cells and proteins.
• Qiagen offers a wide range of specialized nucleic acid purification products based on four highly developed purification technologies, the first is solid-phase and the second is ion-exchange technology and the other is QIAGEN Plasmid Plus technology; silica gel membrane technology; and magnetic particle technology.
• Bio-Rad Laboratories is a leader in developing, manufacturing and marketing a broad range of innovative products for the life science research and clinical diagnostic markets. Bio-Rad used chromatography for blood analysis to identify analytic used in diagnostic tests for diabetes and other diseases.
• Agilent Technologies provides worldwide laboratory equipment, services, consumables, applications and expertise that enable customers to gain the insights they seek.
• Norgen Biotek Corporation is a biotechnology company focused on developing products for sample collection, sample preparation and sample detection as well as providing comprehensive research services to the scientific community.
• Promega Corporation is a key supplier in the fight against Covid-19, developing test kits in research, pharmaceutical and diagnostic laboratories and researching treatment options.
• Purolite Corporation develops and manufactures resin beads used in the most regulated industries to isolate, extract or recover highly specific elements and compounds. Purolite manufactures more than 1,000 active commercial products. The company is a leader in resin-based separation, purification and extraction technologies, providing sustainable solutions for the environment, business and healthcare.
• GE Healthcare, GE's healthcare business, has launched ÄKTA™ Pure, a chromatography system for the flexible, reliable and intuitive purification of proteins.
• Roche has been developing commercial NAP technology for two decades, offering solutions for laboratories of all sizes.

Recent Development:

• In September 2022, Navigo and Mannin sign agreement to develop novel affinity ligand against novel drug for treatment of Covid-19. Navigo Proteins is a protein engineering company and developer of affinity ligands for custom chromatography solutions and Mannin Research Inc. a subsidiary of Mannin GmbH, contracted to develop a Precision X affinity ligand against an angiopoietin-fusion protein and complement 4 binding protein for use in GMP production.
• In September 2022, Novel glucagon-like peptide-1 drugs designed for type 2 diabetes, glucagon like peptide -1 can promote pancreatic beta cell synthesis, inhibit insulin secretion and glucagon release, which has a good therapeutic effect on type 2 diabetes. However, natural glucagon like peptide- 1 is easily degraded by dipeptidyl peptidase-4 in the human body, which limits its therapeutic effect on type 2 diabetes mellitus.

• Thermo Fisher Scientific*
  • Company Overview
  • Product Portfolio
  • Key Highlights
  • Financial Performance
  • Business Strategies
• Merck Millipore
• Qiagen
• Bio-Rad Laboratories
• Agilent Technologies
• Norgen Biotek Corporation
• Promega Corporation
• Purolite Corporation
• GE Healthcare
• Roche

 “*” marked represents similar segmentation in other categories in the respective section