Pain Management Therapeutics Market Size, Share, By Drug Class, Indication, Route of Administration, Distribution Channel, and By Region - Trends, Analysis and Forecast till 2035

• The pain management therapeutics market size is expected to grow at USD 121.9 billion by 2035.
• The target market was value at USD 84.98 billion in 2024.
• Target market is expanding at a CAGR of 4.0%.

Pain management is a medical term that uses a variety of treatments and techniques to diagnose and treat pain. Target Market is driven by rising rate of chronic diseases, increasing number of patients requiring surgeries, such as orthopedic, trauma, and among others. In addition, increasing R&D activities for developing new pain management drugs, rise in number of geriatric populations are another factors propelling growth of the global market. Furthermore, technological advancements, which increases the efficiency and cost-effectiveness of production is also anticipated to create opportunities for growth of the global market over the forecast period.

Key Takeaways:

• North America held the largest share of the market in 2024 due to rising number of patients suffering from chronic diseases.
• Asia Pacific is projected to be the fastest-growing market in the coming years. This is due increase in healthcare expenditure in the region.

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Key Drivers of Target Market:

Rising Number of Chronic Patients to Propel Market Growth

Pain management therapeutics can help people with chronic pain such as diabetes to feel better and improve their quality of life, as its approaches include medications, medical procedures, therapy and complementary medicine techniques. There are many pain management strategies, such as physical therapies, psychological therapies, mind & body techniques are presence for treating chronic diseases.

• For instance, according to the WHO, diabetes is one of the most common chronic conditions in the European region. Europe has the highest rate of type 1 diabetes globally. It is estimated that 1 in 10 people living in the region will have diabetes by 2045. 

Restrains:

Risk of Overdose of Pain Management Therapeutics can hamper the Growth of the Market

The risk of overdose is a major concern regarding medication management, particularly with opioids. Accidental overdose can occur when doses are increased without proper supervision or when medications are mixed with other substance. Overdoes can have serious effect such as respiratory depression, coma, and even death.

• For Instance, according to the WHO, about 600 000 deaths were attributable to drug use in 2019 globally. Approximately 80% of these deaths are related to opioids, with about 25% of those deaths caused by opioid overdose. Approximately 125 000 people died of opioid overdose in 2019. 
• Counterbalance Statements: Death following opioid overdose is preventable if the person receives basic life support and the timely administration of the drug naloxone. Naloxone is an antidote to opioids that will reverse the effects of an opioid overdose if administered in time. Naloxone has virtually no effect in people who have not taken opioids.

Opportunities:

Integration of Advance Technologies will Creates Significant Opportunities in Upcoming Years

The pain management sector has undergone a radical transformation in recent years due to new innovations and technological advancements. It enhance functionality, efficiency, and performance of drugs. Advanced technologies, such as virtual reality providing treatment via modalities, wearable medical technology assisting patients living with chronic pain, artificial intelligence (AI) making use of computational algorithms to organize, predict, and influence future behaviors or outcomes, cloud computing, and psychedelics.  

• For instance, in October 2024, Cleveland Clinic’s scientists have been trying to improve advanced pain management using artificial intelligence (AI) for drug discovery and now, an AI algorithm has identified multiple gut metabolites and US FDA-approved drugs that have potential to be repurposed as non-addictive, non-opioid pain medications. The team used the new AI tool to predict how 369 gut microbial metabolites and 2,308 FDA- approved drugs would interact with 13 pain-associated receptors.

The market is segmented into drug class, indication, route of administration, distribution channel, and region. 

Drug Class

On the basis of drug class, pain management therapeutics market is segmented into NSAIDs, opioids, anesthetics, and others. The opioids segments dominate the target market growth with 29.6% of total share in 2022. This is due to opioids characteristics of high effectiveness, new products, high demand, R & D investment by private and government sector.

• For Instance, In October 2024, The University of Michigan will use a new USD 3.6 million federal grant to study how pain and opioids after surgery impact people with opioid use disorder, how guidelines might be adjusted to address post-surgical pain and how to prevent opioid-related harms.

Indication

The pain management therapeutics market by indication is segmented into arthritic pain, neuropathic pain, chronic back pain, cancer pain, and others. The cancer pain segment holds the largest share of the market due to growing incidence of cancer.

• For Instance, in December 2023, Patients with cancer have another tool in their toolbox for managing pain. Palliative radiation therapy is an effective option for relieving body aches associated with cancer.  High-powered energy eradicates cancer cells, shrinking the tumors and helping to ease agonizing aches.

Route of Administration

The pain management therapeutics market by route of administration is segmented into oral, parenteral, and others. The oral administration segment is expected to dominate the target market growth due to its convenience, easy use, and availability of a variety of oral formulations.

Distribution Channel

On the basis of distribution channel, the market is categorized into online pharmacy, retail pharmacy, and hospital pharmacy. The hospital pharmacy hold the dominant pain management therapeutics market growth due to the high demand for opioids.

Regional

Geographically, the market is studied across North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

North America: North America region is expected to dominate the growth of the market during forecast period due to increasing R & D activities for developing new pain management drugs, increasing cases of chronic disorders, rising geriatric population, increasing healthcare expenditure.

• For instance, according to the Centers for Disease Control & Prevention, About 90% of the annual USD 4.1 trillion health care expenditure is attributed to managing and treating chronic diseases and mental health conditions.
• For instance, according to the Centers for Disease Control & Prevention, Six in 10 Americans have at least one chronic disease, and 4 in 10 have two or more chronic diseases.

Asia Pacific: Asia Pacific region is considered to be the fastest growing region in the target market as countries, such as India, China and many more, are leading the charge significantly due to the increasing investments by major manufacturers, increasing cases of accidents, high production of generics, and among others.

• For Instance, according to the Asian Development Banks, 645,000 number of road accident fatalities in Asia and the Pacific every year. Nearly 3.5 million number of deaths caused by accidents in the last 5 years. 18 million number of individuals permanently disabled due to road accidents in the last 5 years. 22 million number of families that have experienced a family member being killed or permanently disabled by road accidents in the last 5 years. 7 out of 10 number of victims' families that suffer decreased income due to road accidents.

Pain Management Therapeutics Market Report Scope:

Segmentation:

By Drug Class:

• NSAIDs
• Opioids
• Anesthetics
• Others

By Indication:

• Arthritic Pain
• Neuropathic Pain
• Chronic Back Pain
• Cancer Pain
• Others

By Route of Administration:

• Oral
• Parenteral
• Others

By Distribution Channel:

• Online Pharmacy
• Retail Pharmacy
• Hospital Pharmacy

By Region:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • U.K.
  • France
  • Russia
  • Italy
  • Spain
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • Indonesia
  • Malaysia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • Israel
  • South Africa
  • Rest of Middle East & Africa

The key players operating in the Pain Management Therapeutics Market include Teva Pharmaceutical Industries Ltd., Pfizer, and Abbott, among Others. These key players focusing on different organic and inorganic strategies such as acquisition, merger, partnership, agreement, product launch and approval to expand their product portfolio and strengthen their market presence globally.

List of Key Players in the Market:

• Teva Pharmaceutical Industries Ltd.
• Pfizer
• Abbott
• Mallinckrodt Pharmaceuticals
• Endo, Inc.
• GSK Group
• AstraZeneca
• Merck & Co., Inc.
• Novartis AG
• Lilly
• MYLAN N.V.
• Sanofi
• DAIICHI SANKYO COMPANY, LIMITED
• Zoetis Services LLC
• Averitas Pharma

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• In December 2024, Allay Therapeutics, a clinical-stage biotechnology company pioneering ultra-sustained analgesic products to transform post-surgical pain management and recuperation, announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation (BTD) for its lead investigational product ATX101 for the treatment of postsurgical pain following TKA procedures in adults. This BTD was granted based on clinical data from a Phase 2 exploratory dose-ranging trial to treat Post-Surgical Pain following Total Knee Arthroplasty (TKA), or replacement.
• In November 2024, CureLab Oncology, a clinical-stage biotech company dedicated to pioneering innovative therapies, announced a patent application for an innovative chronic pain treatment centered on its p62/SQSTM1 DNA plasmid. This development, which leverages CureLab's chronic inflammation therapeutic, Elenagen, signifies a potential paradigm shift in addressing chronic pain, a pervasive health challenge that affects millions globally.

Analyst View:      

The industry for pain management therapeutics market is placed for substantial growth due to rising rate of chronic diseases, increasing number of patients requiring surgeries, such as orthopedic, trauma, increasing R&D activities for developing new pain management drugs, and rise in number of geriatric populations. New innovations and development, advanced technologies, and several collaborations and partnerships help to boost the growth of the market in the upcoming years.
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