Enzymatic DNA Synthesis Market size is expected to be valuated at USD 16.0 Billion by 2035; Market is driven by Growing Field of Genetic Research and Diagnostics

Method of creating synthetic DNA that uses enzymes (biological catalysts) rather than more traditional chemical processes. Due to several factors, the market for enzymatic DNA synthesis has expanded dramatically. This need is heightened by the growing emphasis on personalized medicine, where unique DNA sequences are essential for developing tailored therapies. Furthermore, because of their speed and affordability, enzymatic approaches are an attractive alternative to conventional chemical synthesis in the expanding fields of genetic research and diagnostics, which require precise and rapid DNA synthesis. The growing prevalence of chronic illnesses and the need for innovative treatment alternatives, such as gene therapy, are driving the market's expansion.

Segmentation Analysis:

By Services	Oligonucleotide Synthesis, and Gene Synthesis
By Application	Synthetic Biology, Genetic Engineering, Vaccine Development, and Others
By End Use	Biopharmaceutical Companies, Academic & Research Institutes, and Others

Report Highlights:

• Enzymatic DNA Synthesis Market size is valuated at USD 6.4 Billion in 2025.
• Target Market size is estimated to be valuated at USD 16.0 Billion by 2035 and at a CAGR of 10.6%.
• Oligonucleotide Synthesis has largest market share in the Enzymatic DNA Synthesis Market.
• Among applications, synthetic biology has the highest share.
• Biopharmaceutical companies are superior in target market growth.
• North America held the largest market share in enzymatic DNA synthesis market size.
• Asia Pacific is fastest growing region in the market.

Market Dynamics:

Growing Factor	Challenge Factor	Market Trend
Increasing Focus on Personalized Medicine	High Upfront Costs	. The Creation of New DNA Polymerases

Key Highlights:

• In May 2025, Telesis Bio announced that it has signed a convertible preferred stock purchase agreement to sell shares of a new series of convertible preferred stock in a private placement.  With the company's recently released patented next-generation enzymatic synthesis platform, Gibson SOLA, customers can take full control of their nucleic acid supply chain, protect valuable intellectual property, and retain ownership of data and insights to feed future generations of AI drug discovery models. The Gibson SOLA reagent platform and comprehensive suite of tools enable customers to perform overnight synthesis of lengthy, complex complexes needed for biologics, vaccines, and cell treatments using standard automated liquid handling equipment.

Report Analysis:

Enzymatic DNA Synthesis Process:

• A DNA primer attached to solid support is exposed to the TdT-dNTP conjugate of the first desired base to add to the primer of the sequence.
• A conjugate extends the primer using its tethered dNTP and then remains covalently attached to the 3’ end, blocking other conjugates from further extending the primer. (1. Extend)
• Cleaving the linker releases TdT from the primer, enabling subsequent extension. (2. De-block)
• The process is repeated with a sequence of conjugates to synthesize the desired DNA sequence.

Browse ∼40 market data tables and ∼35 figures through ∼180 slides and in-depth TOC on “Enzymatic DNA Synthesis Market, By Services (Oligonucleotide Synthesis, and Gene Synthesis), Application (Synthetic Biology, Genetic Engineering, Vaccine Development, and Others), End Use (Biopharmaceutical Companies, Academic & Research Institutes, and Others), and By Region - Trends, Analysis, and Forecast till 2035”

Segmentation:

By Services:

• Oligonucleotide Synthesis
• Gene Synthesis

By Application:

• Synthetic Biology
• Genetic Engineering
• Vaccine Development
• Others

By End Use:

• Biopharmaceutical Companies
• Academic & Research Institutes
• Others

By Region:

• North America
  • U.S.
  • Canada
• Europe
  • Germany
  • U.K.
  • France
  • Russia
  • Italy
  • Spain
  • Netherlands
  • Rest of Europe
• Asia Pacific
  • China
  • India
  • Japan
  • Australia
  • Indonesia
  • Malaysia
  • South Korea
  • Rest of Asia Pacific
• Latin America
  • Brazil
  • Mexico
  • Argentina
  • Rest of Latin America
• Middle East & Africa
  • GCC
  • Israel
  • South Africa
  • Rest of Middle East & Africa

For more insights into the Enzymatic DNA Synthesis Market and its future trends, visit link below: https://www.prophecymarketinsights.com/market_insight/enzymatic-dna-synthesis-market-5834

Competitive Landscape of Enzymatic DNA Synthesis Market:

The key players operating in the Enzymatic DNA Synthesis Market include Telesis Bio Inc., Evonetix, Ansa Biotechnologies, Camena Bioscience, GenScript, DNA Script, Eurofins Scientific, Synbio Technologies, DNA TWOPOINTO, INC., Twist Bioscience, Elegen Corporation, Yeasen, Molecular Assemblies, GenomeWeb, and Bellatrix Aerospace.

Company Name	Telesis Bio Inc.
Headquarter	California, U.S.
CEO	Eric Esser
Employee Count	147 Employees